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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Robo4 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line D407
Methods RT-PCR, qPCR, immunohistochemistry, Western blot, immunocytochemistry, siRNA transfection, MTT assay, Boyden chamber assay, immunocytochemistry, flow cytometry, tube formation assay
Expression pattern associated
Functional description Silencing the expression of Robo4 in RF/6A and RPE cells inhibited their proliferation and reduced their tolerance of hypoxic conditions.
PubMed ID 19495426
Year 2009
Title Expression of Robo4 in the fibrovascular membranes from patients with proliferative diabetic retinopathy and its role in RF/6A and RPE cells.
Drug-related ncRNA NO

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